ENCLOMIMED 25

Description

Enclomiphene Citrate is a selective estrogen receptor modulator (SERM) — a derivative of clomiphene, but consisting only of the enclomiphene isomer, which is the active component responsible for stimulating the body’s own testosterone production.

What it is & what it’s for

• Medical use:
  Primarily developed for male hypogonadism (low testosterone) caused by secondary testicular failure, where the problem lies in the brain’s signaling to the testes rather than in the testes themselves.
• Mechanism:
  Enclomiphene blocks estrogen receptors in the hypothalamus and pituitary. This tricks the brain into thinking estrogen levels are low, so it increases LH (luteinizing hormone) and FSH (follicle-stimulating hormone) secretion. These hormones signal the testes to produce more testosterone and sperm.
• Sports / bodybuilding use:
  Often used in post-cycle therapy (PCT) after anabolic steroid or prohormone use to restore natural testosterone production.

Dosage

Medical

• Common prescription range: 12.5 mg to 25 mg daily (usually in the morning, orally).
• Bloodwork is used to adjust dosage.

Sports / PCT use (unofficial, anecdotal):

• Typical PCT protocol:
  • Week 1–2: 25 mg daily
  • Week 3–4: 12.5 mg daily
    Sometimes combined with other PCT agents (e.g., tamoxifen) depending on cycle length and compounds used.

PCT context

• Goal: Kickstart natural testosterone production and preserve muscle mass while minimizing estrogen rebound after a cycle.
• Why enclomiphene over clomiphene?
  • Clomiphene contains zuclomiphene, an isomer that may cause more mood swings, vision issues, and estrogenic side effects.
  • Enclomiphene isolates the more favorable isomer, so users often report fewer side effects.

Common / popular brand names

• Androxal – original research/trade name in clinical development.
• Enclomid – generic-style brand in research chemical market.
• Enclomiphene – often sold simply under the chemical name by compounding pharmacies and research chem vendors.

Key points & warnings

• Requires prescription in many countries.
• Can cause side effects: headaches, nausea, mood changes, visual disturbances (rare).
• Effectiveness and safety for long-term use in healthy athletes have not been well studied.
• Should be paired with bloodwork to confirm hormone recovery.

Enclomiphene Citrate PCT Example

Goal: Restore natural testosterone production, keep estrogen under control, and preserve muscle mass after a cycle.

Duration: 4–6 weeks

• Shorter cycles (8–10 weeks of mild compounds) → 4 weeks PCT
• Longer/heavier cycles (12+ weeks or strong androgens) → 6 weeks PCT

Weeks 1–2

• Enclomiphene Citrate: 25 mg daily (morning, orally)
• Optional:
  • Nolvadex (Tamoxifen): 10–20 mg daily (if estrogen rebound risk is high)
  • Natural testosterone boosters (zinc, vitamin D, ashwagandha, etc.)

Weeks 3–4

• Enclomiphene Citrate: 12.5 mg daily
• Continue optional Nolvadex if started, same dose.

Weeks 5–6 (only if cycle was heavy/long)

• Enclomiphene Citrate: 12.5 mg every other day
• Gradual taper to allow HPTA to stabilize without a hard stop.

Lifestyle support during PCT

• Training: Keep intensity moderate, reduce volume slightly to avoid overtraining.
• Nutrition: Slight caloric surplus with high protein to support recovery.
• Sleep: Aim for 7–9 hours; poor sleep = poor hormone recovery.
• Avoid alcohol: It blunts testosterone production.

Bloodwork

• Check total testosterone, free testosterone, LH, FSH, estradiol before starting PCT, and again 4 weeks after completion.
• Adjust protocol based on results.

Example brands/formulations

• Androxal – clinical/trial brand
• Enclomid – common research market name
• Pure Enclomiphene Citrate – compounding pharmacies or research labs