Description
Exemestane is a steroidal aromatase inhibitor (AI) designed to reduce estrogen production by permanently binding to the aromatase enzyme. Originally developed for the treatment of hormone-dependent breast cancer, it has gained popularity among athletes and bodybuilders for managing estrogenic side effects caused by anabolic steroid use.
Application in Sports:
Athletes often include Exemestane in their cycle to control water retention, bloating, and gynecomastia. Unlike some other AIs, Exemestane has been reported to support a better lipid profile and maintain healthy IGF-1 levels, which may make it more athlete-friendly. It is considered a “suicidal” inhibitor, meaning it binds permanently and avoids the estrogen rebound effect common with other AIs.
Dosage (athlete use):
- Commonly 12.5 mg every other day
- Some may adjust to 25 mg every other day depending on cycle intensity and individual estrogen response
Side Effects:
- Possible joint pain or stiffness
- Fatigue, low energy, or mood changes if estrogen drops too low
- Decreased bone mineral density with long-term overuse
- Mild negative effects on cholesterol (less pronounced than with other AIs)
Summary:
Exemestane (Aromasin) is a reliable AI for athletes seeking a dry, lean look and protection from estrogen-related side effects during anabolic steroid cycles. Its unique mechanism reduces the chance of rebound and makes it a strong alternative to Anastrozole (Arimidex) or Letrozole.
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